President Obama’s recent letter to Ayatollah Khameini, the forth such personal appeal to Iran’s Supreme Leader, can serve only to undermine efforts at preventing Iran from getting nuclear weapons. Suzanne Maloney writes:

[I]t is precisely at the tactical level that an Obama letter to Khamenei at this juncture appears so spectacularly ill-conceived. First of all, it poses no realistic possibility of advancing progress in the nuclear talks or any other aspect of U.S.-Iranian relations. After all, only the most naive and uninformed observer of Iran would believe that a personal appeal from Obama would sway the Supreme Leader in a positive fashion.

Khamenei’s mistrust and antipathy toward Washington has been a consistent feature of his public rhetoric through the 35-year history of the Islamic Republic. He has described Washington with every possible invective; he indulges in Holocaust denial and 9/11 conspiracies; and he routinely insists that the United States is bent on regime change in Iran and perpetuating the nuclear crisis. These views are not opportunistic or transient. Anti-Americanism is Khamenei’s bedrock, ingrained in his worldview, and as such it is not susceptible to blandishments—particularly not from the very object of his loathing.

Two extraordinary events demonstrate something important about Israel’s most fervent adversaries. One was a speech given at something called The People’s Forum (funded generously by Goldman Sachs), which stated, “When the state of Israel is finally destroyed and erased from history, that will be the single most important blow we can give to destroying capitalism and imperialism.”

The suggestion that this tiny state is the linchpin of a global, centuries-old phenomenon like capitalism goes well beyond anything resembling rational criticism. Even if Israel were guilty of genocide, apartheid, and oppression—which of course it is not—it would not follow that its destruction would help end capitalism or imperialism.

The other was an anti-Israel protest that took place in front of New York City’s Memorial Sloan Kettering Cancer Center, deemed “complicit” in Israel’s evils. At organizers’ urging, participants shouted their slogans at kids in the cancer ward, who were watching from the windows. Given Hamas’s indifference toward the lives of Gazan children, such callousness toward non-Palestinian children from Hamas’s Western allies shouldn’t be surprising. The protest—like the abovementioned speech—deliberately conveyed the message that Israel is the ultimate evil and its destruction the ultimate good, cancer patients be damned.

The fact that Israel’s adversaries are almost comically perverse does not mean that they can be dismissed. If its allies fail to understand the obsessive and irrational hatred that it faces, they cannot effectively help it defend itself.