In 1570, a severe earthquake struck the city of Ferrara; among the survivors was a learned Jew named Azariah de’ Rossi, who thereafter began composing controversial, but widely read, works on Judaism and Jewish history. Henry Abramson describes the disaster’s impact on de’ Rossi’s thinking, and argues that his ideas adumbrated what would now be considered “Modern Orthodoxy.”

Narrowly escaping the collapse of his home, [de’ Rossi] and his family sought refuge with other survivors, Jews and Christians alike, in open fields and even aboard boats on the Po River. His encounter with Christian scholars in the aftermath of the earthquake convinced him to write a religious book, inspired by the earthquake, that described the majesty of God’s universe. [T]itled The Voice of God, [it] was a religious-scientific exploration of the nature and purpose of earthquakes. He surveyed the extant knowledge of the phenomenon from a wide variety of non-Jewish sources, folding it into detailed discussions of rabbinic and biblical passages in a sometimes disjointed and lumpy whole.

[Soon thereafter he began work on his] 700-page magnum opus, titled Light of the Eyes, which caused an intellectually seismic event whose aftershocks would reverberate for the next 500 years. De’ Rossi was broadly inclusive of all wisdoms, regardless of their source. Elements of this orientation are evident in isolated works of Jewish physicians such as Maimonides, but de’ Rossi was much more radical, consulting controversial Jewish thinkers like Philo and Christian ones like Augustine of Hippo.

A child of the burgeoning rationalist humanism of the 16th century, he saw the nondenominational advancement of human wisdom as a garden of intellectual delights, open to visitors of all persuasions and welcoming whatever beneficial seeds might be planted there. Many [devout Jews] would toil in that garden over the next five centuries, but Azariah de’ Rossi was arguably the first to seed the landscape.

Two extraordinary events demonstrate something important about Israel’s most fervent adversaries. One was a speech given at something called The People’s Forum (funded generously by Goldman Sachs), which stated, “When the state of Israel is finally destroyed and erased from history, that will be the single most important blow we can give to destroying capitalism and imperialism.”

The suggestion that this tiny state is the linchpin of a global, centuries-old phenomenon like capitalism goes well beyond anything resembling rational criticism. Even if Israel were guilty of genocide, apartheid, and oppression—which of course it is not—it would not follow that its destruction would help end capitalism or imperialism.

The other was an anti-Israel protest that took place in front of New York City’s Memorial Sloan Kettering Cancer Center, deemed “complicit” in Israel’s evils. At organizers’ urging, participants shouted their slogans at kids in the cancer ward, who were watching from the windows. Given Hamas’s indifference toward the lives of Gazan children, such callousness toward non-Palestinian children from Hamas’s Western allies shouldn’t be surprising. The protest—like the abovementioned speech—deliberately conveyed the message that Israel is the ultimate evil and its destruction the ultimate good, cancer patients be damned.

The fact that Israel’s adversaries are almost comically perverse does not mean that they can be dismissed. If its allies fail to understand the obsessive and irrational hatred that it faces, they cannot effectively help it defend itself.